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q2Xac9UgQf2CyAV6KBgK_thc-cbd-structural-differences

Fortunately, the urine drug screen for THC-COOH is known to have very little cross-reactivity to other cannabinoids that are not psychoactive, such as CBD (cannabidiol), CBG (cannabigerol), CBN (cannabinol), and others. This is good news for “normal” consumers of CBD/hemp oil.

That said, individuals using unusually large doses of a cannabinoid-rich hemp oil product (above 1000-2000 mg of hemp oil daily) could theoretically test positive during the initial urinary screen. Although very rare, the urine screen in these cases would likely represent a “false positive” due to other non-THC metabolites or compounds, which may cross-react with the immunoassay. When this is the case, the confirmatory GC/MS test would be negative, since CBD and other cannabinoids will not be detected by the more accurate (and specific) GC/MS screen.

Keep in mind that most of the high-quality, reliable CBD-rich hemp oil products contain much less THC than marijuana. For example, hemp contains anywhere from 1/10th to 1/300th of the THC concentration found in marijuana. An individual consuming 1000-2000 mg per day of hemp oil would thus consume approximately 3-6 mg of THC. This exceedingly high dose may result in detection of positive urine screen in up to 11% to 23% of assays.

On the other hand, there is some data demonstrating that at daily doses of 0.5mg of THC from 3-5 servings of most commercial CBD-rich hemp oil products, the positive urine screen rate is < 0.2%. Again, most servings of typical high-quality, high-purity CBD-based hemp oil products contain well below 0.1mg of THC and therefore have over 400-600 times less THC than marijuana products.

What does all this mean? Put simply, a consumer who uses a high-quality, scientifically vettedhemp-based product at the standard serving size is highly unlikely to test positive for THC and/or THC-COOH. However, it’s important to be cognizant that extremely high doses may result in a positive urine screen (that would be subsequently shown to be false via GC/MS). Ultimately, consumers need to be fully informed of the specific regulations posed by their employers and adjust their consumption of cannabinoid products accordingly.


Note: Most research suggests that for infrequent or ‘non-daily’ users of cannabis, a typical high-dose marijuana cigarette (containing about 40mg to 50mg of THC) would result in a positive THC metabolite screen for up to two days at this cutoff level. However, for routine and regular users of cannabis, this same screen could be positive for weeks, but this depends on many factors including, but not limited to:

  • how much and how often cannabis is used
  • the metabolism of individual being tested 
  • the route of administration
  • other factors such as medications used, liver or kidney disease, etc.

This article is based on SAMHSA standards. Other organizations’ drug testing standards may vary, so keep in mind that the findings presented in this article may differ under alternative standards. If you have any concern about testing positive for THC when using CBD-containing hemp oil, please seek advice from your health care professional.

References:

Gustafson RA, Kim I, Stout PR, Klette KL, George MP, Moolchan ET, Levine B, Huestis MA. Urinary pharmacokinetics of 11-nor-9-carboxy-delta9-tetrahydrocannabinol after controlled oral delta9-tetrahydrocannabinol administration. J Anal Toxicol. 2004 Apr; 28(3):160-7

Gustafson RA, Levine B, Stout PR, Klette KL, George MP, Moolchan ET, Huestis MA. Urinary cannabinoid detection times after controlled oral administration of delta9-tetrahydrocannabinol to humans. Clin Chem. 2003 Jul; 49(7):1114-24. 

Kemp PM, Abukhalaf IK, Manno JE, Manno BR, Alford DD, Abusada GA. Cannabinoids in humans. I. Analysis of delta 9-tetrahydrocannabinol and six metabolites in plasma and urine using GC-MS. J Anal Toxicol. 1995 Sep; 19(5):285-91. 

Huestis MA, Mitchell JM, Cone EJ. Urinary excretion profiles of 11-nor-9-carboxy-delta 9-tetrahydrocannabinol in humans after single smoked doses of marijuana. J Anal Toxicol. 1996 Oct;20(6):441-52. 

Wall ME, Perez-Reyes M. J Clin Pharmacol. The metabolism of delta 9-tetrahydrocannabinol and related cannabinoids in man. 1981 Aug-Sep; 21(8-9 Suppl):178S-189S.

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